ESWT works through a process called mechanotransduction. The shockwaves act as mechanical stressors that trigger biochemical changes at a cellular level. This influences:
-  Gene expression
 
-  Cell growth and differentiation
 
-  Protein synthesis
 
-  Apoptosis (programmed cell death)
 
-  Tissue regeneration
 
 
Notably, recent studies show ESWT stimulates lubricin production, a key molecule in tendon and septa function.